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Optimized Folate (L-Methylfolate)

Life Extension Optimized Folate with active vitamin B11 as methylfolate (5-MTHF) (1000 mcg / 1700 mcg DFE). For homocysteine, resistance and mental performance. 100 tablets for 100 days.

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Life Extension Optimized Folate

Why vitamin B11 as methylfolate (5-MTHF)?

You can find vitamin B11 in multiple forms as a supplement. Folic acid is the synthetic form and the best known. Folate is the natural form of vitamin B11.

Methylfolate is the active form of vitamin B11 in the body. Folic acid and folate must first be converted to methyl folate before you can use it. Not everyone is equally good at this conversion due to genetic variations in the MTHFR (methylenetetrahydrofolate reductase) gene. You can therefore have a vitamin B11 deficiency even if you take a folate or folic acid supplement.

Methylfolate is immediately effective when you supplement it. This ensures that your vitamin B11 levels are in order, even if you have a less favourable MTHFR gene (or are unaware of this).

Optimized Folate from Life Extension

Life Extension provides methylfolate as a 5-methyl tetrahydrofolate (5-MTHF) calcium salt. This active form of vitamin B11 is 7 times more bioavailable than normal folic acid supplements.

Benefits of vitamin B11

  • contributes to normal metabolism of homocysteine
  • contributes to normal amino acid synthesis
  • contributes to normal mental performance
  • contributes to stress resistance
  • helps to reduce tiredness and fatigue
  • ensures good resistance
  • contributes to the formation of red and white blood cells
  • helps with the process of cell division
  • contributes to tissue growth during pregnancy

More active than 'regular' folate and DFE

5-MTHF is a more active form of vitamin B11 than 'regular' folate. The effect of 5-MTHF is therefore also expressed in terms of activity: Dietary Folate Equivalents (DFE). This means that 1000 mcg of 5-MTHF is as active as 1700 mcg of folate.

Ingredients & Usage

Take 1 tablet a day with a meal. We recommend taking vitamin B11 together with methylcobalamine (active vitamin B12) for the best absorption and effect.

One pack of Life Extension Optimized Folate contains 100 tablets, sufficient for 100 days.

Ingredients per dose 1 tablet % RI
Folate (vitamin B11)
(as (6S)-5-methyl tetrahydrofolate, calcium salt)
1000 mcg** 500 %

RI = Reference Intake.
* RI unknown
** 1700 mcg DFE = Dietary Folate Equivalents (measure of folate activity)

5-Methyltetrahydrofolate, microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

Allergy information
No allergens listed

Store dry, cool, away from light and outside of reach of young children.

Dietary supplement. Category: Vitamins.
A varied and balanced diet and a healthy lifestyle are important. Food supplements are no substitute for a varied diet.


  • Do not exceed recommended dose.
  • Do not use if outer seal is broken or damaged.
  • If you are undergoing treatment for a medical condition or if you are pregnant or lactating, please consult your medical practitioner first.

Made in the United States.

Quality Supplements and Vitamins, Inc
Ft. Lauderdale
FL 33309
United States

Imported by
Life Extension Europe
Prins Hendriklaan 28
1075 BD Amsterdam
The Netherlands