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Optimized Folate (L-Methylfolate)

Life Extension Optimized Folate with active vitamin B11 as methylfolate (5-MTHF). For homocysteine, resistance and mental performance. 100 tablets for 100 days.

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Why vitamin B11 as methylfolate (5-MTHF)?

You can find vitamin B11 in multiple forms as a supplement. Folic acid is the synthetic form and the best known. Folate is the natural form of vitamin B11.

Methylfolate is the active form of vitamin B11 in the body. Folic acid and folate must first be converted to methyl folate before you can use it. Not everyone is equally good at this conversion due to genetic variations in the MTHFR (methylenetetrahydrofolate reductase) gene. You can therefore have a vitamin B11 deficiency even if you take a folate or folic acid supplement.

Methylfolate is immediately effective when you supplement it. This ensures that your vitamin B11 levels are in order, even if you have a less favourable MTHFR gene (or are unaware of this).

Optimized Folate from Life Extension

Life Extension provides methylfolate as a 5-methyl tetrahydrofolate (5-MTHF) calcium salt. This active form of vitamin B11 is 7 times more bioavailable than normal folic acid supplements.

Benefits of vitamin B11

  • contributes to normal metabolism of homocysteine
  • contributes to normal amino acid synthesis
  • contributes to normal mental performance
  • contributes to stress resistance
  • helps to reduce tiredness and fatigue
  • ensures good resistance
  • contributes to the formation of red and white blood cells
  • helps with the process of cell division
  • contributes to tissue growth during pregnancy

Ingredients & Use

Take 1 tablet a day with a meal. We recommend taking vitamin B11 together with methylcobalamine (active vitamin B12) for the best absorption and effect.

One pack of Life Extension Optimized Folate contains 100 tablets, sufficient for 100 days.

Ingredients per dose 1 tablet % RDA
Folate (vitamin B11) (as (6S)-5-methyl tetrahydrofolate, calcium salt) 1000 mcg 500 %

RDA = recommended daily reference intake based on a daily intake of 2000 kcal.
* RDA unknown

Other ingredients: Microcrystalline cellulose, dicalcium phosphate, croscarmellose sodium, silica, vegetable stearate, stearic acid.

Life Extension Optimized Folate is a dietary supplement in the vitamins category and is not a substitute for a varied and balanced diet and/or healthy lifestyle.

Keep dry and cool.


  • Do not exceed the recommended dose.
  • Do not use if the package seal is damaged when purchased.
  • First consult your doctor if you are being treated for a medical condition, are pregnant or breastfeeding.
  • Keep out of reach of children

Life Extension Europe
Frankfurtstraat 38
1175 LH Lijnden
The Netherlands


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Shipping & delivery

See shipping and returns for more information.


Can I return my order if the product does not meet my needs?

Yes, that is possible. You can return the product within 14 days of return. The costs are at your expense.

Read more about shipping and returns.

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